Denosumab: BMD after initiation
There is no consensus on the optimal frequency of monitoring and preferred site to monitor (UpToDate – Guidelines for monitoring response to therapy)
- Recommendations range from against monitoring (American College of Physicians) to every one to two years
- Don’t routinely repeat DXA scans more often than once every two years – ChoosingWisely (American College of Rheumatology)
Bone density changes slowly and the magnitude of change over a shorter durations may be due to measurement error
Thus, bone density should be checked when the results influence clinical management or at the point of a significant expected change in bone mineral density.
Our expert opinion recommendation is to recheck BMD in 2 years to ensure bone density is not dropping as this would prompt further evaluation.