Denosumab: Correct Risk of Hypocalcemia

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Denosumab: Correct Risk of Hypocalcemia

If serum calcium is low, evaluate etiology

  • Consider parathyroid, thyroid, malabsorption

Evaluate calcium and vitamin D intake from all sources

  • Calcium: Women 50+ and Men 70+ need 1,200 mg daily. All else need 1,000 mg daily
  • Vitamin D: All adults 50+: ~600-800 international units daily
    • Supplement to goal of 30+ ng/dL. Best evidence for empiric supplementation is for older adults living in residential care because they are more likely to be deficient.

If advanced renal disease, eGFR <30, coordinate care with nephrology to ensure risk factors for hypocalcemia are being addressed.